The seemingly insignificant thing which causes the inability or unwillingness to endure any more of the burden.
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The name of the letter writer is always changed, and usually there is no mention of city, state, or country. Trouble is the same everywhere. The letters read as if they came from your next-door neighbor, and they might have. Or they might have come from Australia, South Africa, or Spain.
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Invade – to enter as if to take possession, to intrude upon.